Endocrine Abstracts

Fibrous dysplasia of bone/McCune-Albright syndrome (FD/MAS) is due to a somatic activating GNAS mutation. Patients may be asymptomatic in monostotic forms, which represent two thirds of cases. In those forms, the diagnosis is often incidental. But these monostotic FD may also be revealed by bone pain, bone deformity or fracture. The diagnosis is generally made in childhood or in young adults. Polyostotic FD is often more severe, with a higher incidence of fragility fracture. I...

Fibrous dysplasia of bone (FD) – a rare disease due to osteoblastic lineage differentiation defects – is associated with bone pain, fracture and bone deformity, but few therapeutic options are available. Antiresorptive agents such as bisphosphonates may be of interest because there is evidence of increased osteoclastic activity in FD bone lesions, even if the disease is due to an osteoblastic defect.We have reviewed published data on the treatm...

Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...

Introduction: Pheochromocytoma and most abdominal paraganglioma (PPGL) can secrete catecholamines. In vitro and in vivo, catecholamines modulate bone remodeling by stimulating bone resorption. In patients with PPGL, four studies have previously demonstrated an increase of biological markers of bone resorption, a decreased of bone density and a higher prevalence of vertebral fractures. We report two patients with malignant abdominal secreting paraganglioma pre...